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Centessa Pharmaceuticals plc, together with its subsidiaries, discovers, develops, and delivers orexin-based neuroscience therapeutics in the United Kingdom and the United States. The company develops ORX750, an orexin receptor 2 agonist, which is in Phase IIa clinical trial for the treatment of central disorders of hypersomnolence, including narcolepsy type 1 and 2, as well as idiopathic hypersomnia. It also engages in the development of ORX142 which is in Phase I clinical trial for the treatment of neurological and neurodegenerative disorders; ORX489 which is in Phase I clinical trial for the treatment of neuropsychiatric disorders; and LockBody, an early-stage immuno-oncology program technology platform. The company was incorporated in 2020 and is headquartered in Altrincham, the United Kingdom.

	2021	2022	2023	2024	2025	TTM
Revenue
Total revenue	-	-	6.853	-	15	-
COGS	0.034	0.130919	0.813139	0.942396	-	-
Gross Profit	(0.034)	(0.131)	6.853	(0.942396)	15	-
Operating Expenses & Income
Operating Income	(374.9)	(212.3)	(171.3)	(201.1)	(207.7)	(256.7)
Total Operating Expenses	374.9	212.3	178.1	201.1	222.7	256.7
R&D Expenses	96.32	155.1	124.4	150.2	172.2	198.7
Selling General & Admin Expenses	43.01	55.2	53.73	50.81	50.47	58.02
Earnings from Continuing Operations
Interest Expense	(2.548696)	(7.277)	(9.906)	(10.09)	(11.46)	(11.31)
Interest Income	-	0.244	10.48	14.02	20.53	17.77
Income Tax Expense	0.114	(0.747)	(25.06)	2.844	1.819	1.272
Net Income
Net Income	(381.9)	(216.2)	(151.1)	(235.8)	(197.5)	(250.6)
Supplemental
EBIT	(139.3)	(209.7)	(166.2)	(222.8)	(184.3)	(261.5)
EBITDA	(139.3)	(209.5)	(165.4)	(221.9)	(183.3)	(260.6)

Centessa Pharmaceuticals PLC ADR